How to Relieve Side Effects of Prednisone. Approaches to traditional treatments often rely on one cure-all medication that can be used to treat a number of different. Prednisone and other corticosteroid pills, creams and injections can cause side effects. Common side effects of prednisone include: Headache; Dizziness; Trouble sleeping; Inappropriate happiness; Severe mood swings; Personality change; Bulging eyes Consumer ratings reports for PREDNISONE. Includes 532 patient rankings on scale of 1-5, comments, side effects, dosage, sex, age, time taken. Page 1 of 9 Prednisone is a valuable medication for many serious conditions, but it can also carry grave consequences including psychological reactions. Learn about the potential side effects of prednisone. Includes common and rare side effects information for consumers and healthcare professionals. Prednisone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: headache; dizziness; difficulty falling asleep. Prednisone is used to treat allergic disorders, ulcerative colitis, psoriasis and arthritis. Learn about side effects, interactions and indications. Find a comprehensive guide to possible side effects when taking Deltasone (Prednisone) for Professionals, Patients, and Caregivers. Prednisone (brand: Rayos and others) is a medication that treats inflammation in conditions like multiple sclerosis and rheumatoid arthritis. Learn more.